Marumo K, Nakamura Y, Fukuda S
Department of Clinical Pathology, Showa University Fujigaoka Hospital, Yokohama.
Rinsho Byori. 1995 Nov;43(11):1140-6.
The clinical isolates of Serratia marcescens in The Showa University Fujigaoka Hospital in the period V during the 3 years from 1991 April to 1994 March were epidemiologically investigated by determining O-antigens, biotypes and antimicrobial susceptibilities. The isolates were collected, while the consumption of beta-lactam antibiotics, new quinolones, and aminoglycosides in the hospital had not changed significantly since 1991. The urease positive O3 strains were predominantly isolated in the period II to IV during the 9 years and 3 months from 1982 January to 1991 April and were more resistant to third generation cephalosporins and the other drugs such as new quinolones and aminoglycosides than the other O-serotype strains. However, the urease negative O14 strains, unlike such O3 strains, were predominantly isolated in the period V and were more resistant to the above mentioned drugs than the other O-serotype strains, indicating that they had higher resistance rates for carbenicillin, latamoxef, ceftizoxime, cefoperazone, cefpirome, tobramycin, dibekacin, gentamicin and fosfomycin than the O3 strains in the period IV during the two years and three months from 1989 January to 1991 March. The hospital wards in which the O14 strains were mainly isolated were the departments of urology, general surgery, orthopedic surgery, haematology, and internal secretion and kidney medicines, corresponding to those in which the isolation number of the O3 strains decreased in the period V. These findings suggest that S. marcescens resident in the hospital inherits multiple drug resistance by changing the biotype and O-serotype.
1991年4月至1994年3月的3年期间，对昭和大学藤冈医院的粘质沙雷氏菌临床分离株进行了O抗原、生物型和抗菌药敏试验的流行病学调查。这些分离株是在医院β-内酰胺类抗生素、新型喹诺酮类药物和氨基糖苷类药物的消耗量自1991年以来未发生显著变化的情况下收集的。在1982年1月至1991年4月的9年零3个月期间的第II至IV阶段，主要分离出脲酶阳性O3菌株，与其他O血清型菌株相比，它们对第三代头孢菌素以及新型喹诺酮类和氨基糖苷类等其他药物的耐药性更强。然而，脲酶阴性O14菌株与O3菌株不同，主要在第V阶段分离得到，并且比其他O血清型菌株对上述药物的耐药性更强，这表明在1989年1月至1991年3月的两年零三个月期间的第IV阶段，它们对羧苄青霉素、拉氧头孢、头孢唑肟、头孢哌酮、头孢匹罗、妥布霉素、地贝卡星、庆大霉素和磷霉素的耐药率高于O3菌株。主要分离出O14菌株的医院病房是泌尿外科、普通外科、整形外科、血液科以及内分泌和肾脏内科，这与第V阶段O3菌株分离数量减少的病房相对应。这些发现表明，医院内的粘质沙雷氏菌通过改变生物型和O血清型继承了多重耐药性。
