Nagao M, Zhang W D, Takatori T, Itakura Y, Yamada Y, Iwase H, Oono T, Iwadate K
Department of Forensic Medicine, Faculty of Medicine, University of Tokyo, Japan.
Nihon Hoigaku Zasshi. 1994 Jun;48(3):166-8.
We reported the immunohistochemical identification of paraquat in the immune and hematopoietic systems such as bone marrow, spleen and thymus. Twelve paraquat-poisoned rats were sacrificed in 3 h, 12 h, 3 days, 7 days and 10 days after intravenous administration of paraquat. In the bone marrow, paraquat was localized in several types of blood cells (granulocyte, erythrocyte and megakaryocyte) and their precursors between 24 h and 7 days after the injection. In the thymus, paraquat was mainly localized in the medulla between 12 h and 7 days after the injection, whereas in the spleen, it was mainly localized in the red pulp between 12 h and 10 days after administration of paraquat.
我们报告了在骨髓、脾脏和胸腺等免疫及造血系统中百草枯的免疫组织化学鉴定结果。将12只经百草枯中毒的大鼠在静脉注射百草枯后的3小时、12小时、3天、7天和10天处死。在骨髓中，注射后24小时至7天内，百草枯定位于几种类型的血细胞（粒细胞、红细胞和巨核细胞）及其前体细胞中。在胸腺中，注射后12小时至7天内，百草枯主要定位于髓质，而在脾脏中，百草枯给药后12小时至10天内主要定位于红髓。
