Nagao M, Zhang W D, Itakura Y, Kobayashi M, Yamada Y, Yagi K, Oono T, Takatori T
Department of Forensic Medicine, Faculty of Medicine, University of Tokyo, Japan.
Nihon Hoigaku Zasshi. 1993 Jun;47(3):202-6.
Immunohistochemical techniques were used to observe the localization of paraquat in the skin and eyes of rats. Paraquat poisoned rats were killed 3 h, 12 h, 24 h, 3 days, 7 days and 10 days after intravenous administration of paraquat. In skin, paraquat was localized in the ducts of sweat glands and sebaceous glands between 3 and 10 days after paraquat injection. In eyes, weak positive findings were observed in nerve fibers of retina between 3 and 10 days after the injection. In cornea, paraquat was localized in epithelial cells at the first 3 h and between 3 and 10 days after paraquat administration. Since skin occupies a vast area of the body in animals, as an organ, it seems to be an important storage pool for the redistribution of paraquat.
采用免疫组织化学技术观察百草枯在大鼠皮肤和眼睛中的定位。静脉注射百草枯后3小时、12小时、24小时、3天、7天和10天处死百草枯中毒大鼠。在皮肤中，百草枯注射后3至10天定位在汗腺和皮脂腺导管中。在眼睛中，注射后3至10天在视网膜神经纤维中观察到弱阳性结果。在角膜中，百草枯在给药后最初3小时以及3至10天定位在上皮细胞中。由于皮肤在动物体内占据身体的大面积，作为一个器官，它似乎是百草枯重新分布的重要储存库。
