Kitao Y, Yamane T, Kikuoka N, Matsumoto H, Oya K, Inagake M, Takahashi T
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
J Surg Oncol. 1994 Sep;57(1):22-4. doi: 10.1002/jso.2930570107.
Gastric ornithine decarboxylase (ODC) activity was measured as a biomarker of tumor-promoting activity in the remnant stomach of rats and humans. Gastrectomy of Wistar rats utilizing the Billroth I method caused a significantly high induction of ODC, and use of the Billroth II method caused a significantly higher induction of ODC than the Billroth I method. In humans, ODC activity of remnant gastric cancer tissue, normal-appearing mucosa of remnant gastric cancer patient, and remnant gastric mucosa without cancer after the Billroth II method were significantly higher than that of normal gastric mucosa without gastrectomy. ODC activity of remnant gastric mucosa without cancer after the Billroth II method was significantly higher than that after the Billroth I method. Risk of carcinogenesis was high in the remnant stomach, especially after the Billroth II method.
胃鸟氨酸脱羧酶（ODC）活性作为大鼠和人类残胃中促肿瘤活性的生物标志物进行测定。采用毕罗氏Ⅰ法对Wistar大鼠进行胃切除术后，ODC的诱导水平显著升高，而采用毕罗氏Ⅱ法导致的ODC诱导水平显著高于毕罗氏Ⅰ法。在人类中，毕罗氏Ⅱ法术后残胃癌组织、残胃癌患者外观正常黏膜以及无癌残胃黏膜的ODC活性显著高于未行胃切除术的正常胃黏膜。毕罗氏Ⅱ法术后无癌残胃黏膜的ODC活性显著高于毕罗氏Ⅰ法术后。残胃尤其是毕罗氏Ⅱ法术后发生癌变的风险较高。
