小鼠中结核感染过继免疫的转移
Transfer of adoptive immunity to tuberculosis in mice.
作者信息
Lefford M J
出版信息
Infect Immun. 1975 Jun;11(6):1174-81. doi: 10.1128/iai.11.6.1174-1181.1975.
Abstract
A system is described for studying adoptive immunity to tuberculosis in syngeneic mice. Donor mice were immunized with 10(4) BCG intravenously, and lymphoid cells were harvested 28 days later. Adoptive immunity was measured in recipient mice in terms of the inhibition of growth of BCG in the liver and spleen following intravenous injection. Adoptive immunity was expressed optimally when recipients were sublethally irradiated (500 R), challenged with 10(4) to 10(5) viable organisms, and given sensitized lymphoid cells intravenously. Adoptive immunity was not manifest until 14 days after challenge and was effective against Mycobacterium tuberculosis H37Rv as well as BCG. Immunity could be conferred by spleen, lymph node, peritoneal exudate, and resident peritoneal (washout) cells. The lymphoid cells conferring immunity were shown to be thymus-dependent lymphocytes by virtue of their nonadherence to glass wool and sensitivity to anti-theta serum plus complement. The sensitized cells were relatively susceptible to both in vitro and in vivo X-irradiation.
摘要
描述了一种用于研究同基因小鼠对结核病的过继免疫的系统。供体小鼠经静脉注射10⁴个卡介苗（BCG）进行免疫，28天后采集淋巴细胞。通过静脉注射后测量受体小鼠肝脏和脾脏中卡介苗生长的抑制情况来检测过继免疫。当受体小鼠接受亚致死剂量照射（500伦琴）、用10⁴至10⁵个活菌体进行攻击并经静脉给予致敏淋巴细胞时，过继免疫表现最佳。过继免疫在攻击后14天才显现，并且对结核分枝杆菌H37Rv以及卡介苗均有效。脾脏、淋巴结、腹腔渗出液和腹腔驻留（冲洗）细胞均可赋予免疫。赋予免疫的淋巴细胞因其不黏附于玻璃棉且对抗θ血清加补体敏感而被证明是胸腺依赖性淋巴细胞。致敏细胞在体外和体内对X射线照射都相对敏感。
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