Gorsky M, Raviv M, Raviv E
Department of Oral Pathology and Oral Medicine, Maurice and Gabriela Goldschleger School of Dental Medicine, Tel Aviv University, Israel.
Oral Surg Oral Med Oral Pathol. 1994 Jun;77(6):620-2. doi: 10.1016/0030-4220(94)90322-0.
Pemphigus vulgaris, a chronic autoimmune vesiculobullous disease, affects people in their fifth or sixth decade of life. Involvement in adolescence is rare with only about 30 cases reported in the last 35 years. This article presents a case of adolescent pemphigus vulgaris in a 15-year-old girl with oral and skin lesions. The patient has been free of lesions with a maintenance dosage of 10 mg of prednisone every other day. The mean age of the 31 patients, including our patient, was 14 years. Skin involvement was reported in 87% of patients, oral involvement in 87%, and skin and oral lesions in 81% with oral lesions preceding skin lesions. Early diagnosis of adolescent pemphigus vulgaris is important to eliminate or reduce the severity of further intraoral or extraoral involvement. The term adolescent pemphigus vulgaris is suggested when the onset is between 12 and 18 years of age.
寻常型天疱疮是一种慢性自身免疫性水疱大疱性疾病，好发于50或60岁人群。青春期发病罕见，过去35年仅有约30例报道。本文介绍了一名15岁患寻常型天疱疮的青春期女孩，有口腔和皮肤损害。患者每隔一天服用10mg泼尼松维持剂量，目前无皮损。包括我们的患者在内的31例患者的平均年龄为14岁。87%的患者有皮肤受累，87%有口腔受累，81%有皮肤和口腔损害，且口腔损害先于皮肤损害。青春期寻常型天疱疮的早期诊断对于消除或减轻进一步的口腔内或口腔外受累的严重程度很重要。当发病年龄在12至18岁之间时，建议使用青春期寻常型天疱疮这一术语。
