Robinson J C, Lozada-Nur F, Frieden I
Department of Stomatology, University of California, San Francisco, USA.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1997 Oct;84(4):349-55. doi: 10.1016/s1079-2104(97)90030-5.
Twelve cases of oral pemphigus vulgaris are described to illustrate the long-term behavior of the disease and the treatment challenges it presents to the oral medicine practitioner. In addition, we review the literature on oral pemphigus vulgaris with respect to clinical history, signs and symptoms, management, and treatment outcome. Pemphigus vulgaris is a chronic vesiculobullous disease with a potentially fatal outcome. Mortality from pemphigus vulgaris before the development of effective therapies was as high as 90%. Today, with treatment, it is closer to 10%. Involvement of the oral mucosa is common and in most cases precede skin lesions; in our patients, the oral lesions preceded the development of extraoral disease in 75% of cases. Pemphigus vulgaris was more frequent among women (9:3), and there was a tendency for the severity and frequency of disease to decrease with time.
本文描述了12例寻常型天疱疮患者的情况，以说明该病的长期病程以及给口腔医学从业者带来的治疗挑战。此外，我们还回顾了关于寻常型天疱疮的临床病史、体征和症状、管理及治疗结果的文献。寻常型天疱疮是一种慢性水疱性疾病，可能会导致致命后果。在有效治疗方法出现之前，寻常型天疱疮的死亡率高达90%。如今，经过治疗，死亡率接近10%。口腔黏膜受累很常见，且在大多数情况下先于皮肤病变出现；在我们的患者中，75%的病例口腔病变先于口外疾病出现。寻常型天疱疮在女性中更为常见（9例女性对3例男性），并且疾病的严重程度和发作频率有随时间降低的趋势。
