Van Steirteghem A, Liu J, Joris H, Nagy Z, Staessen C, Camus M, Wisanto A, Van Assche E, Devroey P
Centre for Reproductive Medicine, University Hospital and Medical School, Vrije Universiteit Brussel, Belgium.
Reprod Fertil Dev. 1994;6(1):85-9; discussion 89-91. doi: 10.1071/rd9940085.
The results of 600 consecutive treatment cycles of subzonal insemination (SUZI) and intracytoplasmic sperm injection (ICSI) are described in couples with failed fertilization after standard IVF or insufficient spermatozoa in the ejaculate for IVF. More oocytes were damaged by ICSI (16.3%) than by SUZI (8.5%) and the normal fertilization rate was substantially higher after ICSI (49.1% v. 16.6%). Subsequent development of two-pronuclear oocytes in vitro was 80% after SUZI and 73.9% after ICSI. Significantly more triple embryo replacements were carried out after ICSI than after SUZI. Embryo transfers were possible in 421 of the 600 cycles. There were 63 pregnancies after ICSI (215 transfers) and 23 after SUZI (156 transfers); 10 additional pregnancies were achieved after 50 transfers of a mixture of SUZI and ICSI embryos. The results of fetal karyotypes and follow-up of the children do not indicate an increase in congenital malformations.
本文描述了600个连续的卵母细胞浆内单精子注射（ICSI）和透明带下授精（SUZI）治疗周期的结果，这些治疗针对的是标准体外受精（IVF）后受精失败或精液中精子数量不足而无法进行IVF的夫妇。与SUZI（8.5%）相比，ICSI对更多的卵母细胞造成了损伤（16.3%），且ICSI后的正常受精率显著更高（49.1%对16.6%）。SUZI后双原核卵母细胞的体外后续发育率为80%，ICSI后为73.9%。与SUZI相比，ICSI后进行三胚胎移植的情况明显更多。600个周期中有421个周期进行了胚胎移植。ICSI（215次移植）后有63例妊娠，SUZI（156次移植）后有23例妊娠；50次SUZI和ICSI胚胎混合移植后又有10例妊娠。胎儿核型结果及对儿童的随访未显示先天性畸形增加。
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