Uchaĭkin V F, Kaganov B S, Kovalev O B, Karetnyĭ Iu V, Konev V A, Stepanov A N, Syr'eva T N, Chaplygina G V
Zh Mikrobiol Epidemiol Immunobiol. 1993 May-Jun(3):90-5.
The clinical picture, course and outcomes of hepatitis A developing as a superinfection in children with chronic hepatitis B virus (HBV) infection, hospitalized in connection with acute viral hepatitis, were determined on the basis of the dynamic clinico-laboratory investigation and identification of viral hepatitides A, B and delta by the method of enzyme immunoassay. In all children hepatitis B virus surface antigen (HBsAg), i.e. the serological sign of HBV infection, and anti-HAV IgG, the serological sign of hepatitis A virus (HAV) infection, were present in the blood. 11 out of 12 children had never before been examined for diseases of the liver. Only in one child chronic HBsAg carriership had been detected 14 months before this hospitalization. Considering the data of epidemiological history and clinical observations, as well as the results of serological survey, these children were found to have hepatitis A superimposed on chronic HBV infection. As revealed in the present investigation, in cases of HAV superinfection observed simultaneously with chronic hepatitis B viral hepatitis A was manifested by typical clinico-laboratory symptoms.
对因急性病毒性肝炎住院的慢性乙型肝炎病毒（HBV）感染儿童中发生的甲型肝炎重叠感染的临床表现、病程及转归，通过动态临床实验室检查以及采用酶免疫分析法对甲型、乙型和丁型病毒性肝炎进行鉴定来确定。所有儿童血液中均存在乙型肝炎病毒表面抗原（HBsAg），即HBV感染的血清学标志，以及甲型肝炎病毒（HAV）感染的血清学标志抗-HAV IgG。12名儿童中有11名此前从未接受过肝脏疾病检查。仅1名儿童在此次住院前14个月被检测出慢性HBsAg携带状态。综合流行病学病史和临床观察数据以及血清学调查结果，发现这些儿童为慢性HBV感染基础上重叠甲型肝炎感染。本次调查显示，在慢性乙型肝炎同时发生HAV重叠感染的病例中，甲型肝炎表现出典型的临床实验室症状。
