Petruson B
ENT-Department, University of Göteborg, Sahlgren's Hospital, Sweden.
Acta Otolaryngol Suppl. 1994;515:33-6; discussion 36-7. doi: 10.3109/00016489409124321.
The number of goblet cells in the normal mucosa in the paranasal sinuses is comparable to that in the nasal mucosa. There are relatively few mucosal glands in the sinuses. In recent years, the maxillary sinus of the rabbit has been used for experimental studies. After induced infections, the number of goblet cells increases. In pneumococcal sinusitis, the number reaches a peak after 3 weeks and then declines. In sinusitis induced by St. aureus and the anaerobic bacteria B. fragilis, the number is more progressive over time and persistent during 12 weeks. The number of glands shows no hyperplasia, but occasionally atypical glands can be found. In patients with chronic sinusitis, the number of goblet cells is usually not affected but the number of glands increases, and the glands usually have a pathological shape. A decreased ciliary beating frequency correlates well with an increase in number of goblet cells. However, 75% of patients with chronic sinusitis have a normal frequency. When performing studies in patients with sinusitis one should be aware of the dynamic course of the disease and the difficulty in evaluating single mucosal biopsies.
鼻窦正常黏膜中杯状细胞的数量与鼻黏膜中的相当。鼻窦中的黏膜腺相对较少。近年来，兔的上颌窦已被用于实验研究。诱导感染后，杯状细胞数量增加。在肺炎球菌性鼻窦炎中，数量在3周后达到峰值，然后下降。在由金黄色葡萄球菌和脆弱拟杆菌等厌氧菌引起的鼻窦炎中，数量随时间推移增加更为明显，并在12周内持续存在。腺体数量无增生，但偶尔可发现非典型腺体。在慢性鼻窦炎患者中，杯状细胞数量通常不受影响，但腺体数量增加，且腺体通常具有病理形态。纤毛摆动频率降低与杯状细胞数量增加密切相关。然而，75%的慢性鼻窦炎患者频率正常。在对鼻窦炎患者进行研究时，应注意疾病的动态过程以及评估单次黏膜活检的难度。
