Hirasaka T, Namiki M, Katakami C, Yamamoto M
Department of Ophthalmology, Shinsuma Hospital, Hyogo-ken, Japan.
Nippon Ganka Gakkai Zasshi. 1994 Jul;98(7):636-40.
We investigated histologically wound adaptation and healing after self-sealing cataract surgery in rabbits in the early postoperative period. A scleral pocket (4 mm wide, 2 mm long) and an internal corneal flap (2 mm long) were made in one eye in a series of rabbits. After phacoemulsification, a balanced salt solution was injected to self-seal the wound (self-sealing group). After the same procedures were performed in the contralateral eye, a horizontal 9-0 nylon suture was placed in the wound (suture group). On the first day after operation, the adaptation of the wound was better in the suture group than in the self-sealing group. On the fourth day, the scleral wound space was filled with fibroblastic cells and fibrin-like substance, and activated keratocytes had accumulated along the corneal wound. Although inflammatory cells collected around the suture in the suture group, there was no remarkable difference between the two groups on the seventh day. These results indicated that the adaptation of the wound in the early period was different between the self-sealing group and the suture group, and that the difference might result in different peripheral corneal curvature. This might be one of the causes of the postoperative astigmatism in the early stage.
我们对兔自密封白内障手术后早期的伤口适应性和愈合情况进行了组织学研究。在一系列兔子的一只眼睛上制作了一个巩膜袋（宽4毫米，长2毫米）和一个角膜内瓣（长2毫米）。超声乳化术后，注入平衡盐溶液以自密封伤口（自密封组）。在对侧眼进行相同操作后，在伤口处放置一根水平的9-0尼龙缝线（缝线组）。术后第一天，缝线组伤口的适应性优于自密封组。第四天，巩膜伤口间隙充满成纤维细胞和纤维蛋白样物质，活化的角膜细胞沿角膜伤口积聚。虽然缝线组缝线周围有炎性细胞聚集，但两组在第七天没有显著差异。这些结果表明，自密封组和缝线组早期伤口的适应性不同，这种差异可能导致周边角膜曲率不同。这可能是早期术后散光的原因之一。
