Isenberg J, Ko H, Pulverer G, Grundmann R, Stützer H, Pichlmaier H
Klinik und Poliklinik für Chirurgie, Universität zu Köln, Germany.
Anticancer Res. 1994 May-Jun;14(3B):1399-404.
In order to improve the perioperative resistance to the spread of cancer during operation the effect of preoperative stimulation of the immunesystem by Propionibacterium granulosum KP-45 was investigated in patients with colorectal carcinoma. In a prospective randomized trial 101 patients were allocated to either treatment (n = 51) or control (n = 50). In the treatment 10 mg of Propioni bacteria were administered intravenously between the seventh and third day prior to surgical treatment. At the time of operation 21 tumours were classified as stage I (treatment n = 12, control n = 9), 22 as stage II (treatment n = 10, control n = 2). Postoperatively wound infections requiring treatment were more prevalent in the control group (n = 4) than in the treated group (n = 0). All patients were subsequently followed up for 76 months. For stage I carcinoma the survival rates, excluding perioperative deaths, were 91% in the treated and 63% in the control group respectively. One case of tumour metastasis was seen in the control group. For stage II carcinoma the survival rate was 90% for the treated group with distant spread in 1 case and 45% in the control group where the rate of recurrence was 55%. For stages III and IV there was no statistically significant difference in survival between the treated and the control groups.
为了提高手术期间围手术期对癌症扩散的抵抗力，研究了颗粒丙酸杆菌KP - 45术前刺激免疫系统对结直肠癌患者的影响。在一项前瞻性随机试验中，101例患者被分为治疗组（n = 51）或对照组（n = 50）。治疗组在手术治疗前第7天至第3天静脉注射10mg丙酸杆菌。手术时，21个肿瘤被分类为I期（治疗组n = 12，对照组n = 9），22个为II期（治疗组n = 10，对照组n = 2）。术后需要治疗的伤口感染在对照组（n = 4）中比治疗组（n = 0）更普遍。所有患者随后均随访76个月。对于I期癌，排除围手术期死亡后的生存率，治疗组为91%，对照组为63%。对照组出现1例肿瘤转移。对于II期癌，治疗组的生存率为90%，有1例远处转移，对照组为45%，复发率为55%。对于III期和IV期，治疗组和对照组之间的生存率无统计学显著差异。
