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犬类常见虎蛇(盾鼻蛇属)毒液中毒临床效应的一些毒性阈值。

Some toxicity thresholds for the clinical effects of common tiger snake (Notechis scutatus) envenomation in the dog.

作者信息

Lewis P F

出版信息

Aust Vet J. 1994 May;71(5):133-5. doi: 10.1111/j.1751-0813.1994.tb03365.x.

DOI:10.1111/j.1751-0813.1994.tb03365.x
PMID:8067945
Abstract

Common tiger snake (Notechis scutatus) venom was administered experimentally to dogs at doses from 0.25 lethal dose (LD) to 20 LD. Haemolysis and increased creatine kinase values occurred rapidly after injection of sublethal (subparalytic) doses, but the clotting time of blood was extended and blood became incoagulable only when dogs were dosed with 10 LD or more of venom. Haemolysis, although of a low threshold of toxicity, was not severe and should not greatly affect the lethality of the venom. Coagulopathy is a sign that the dog has been lethally envenomed and will need to be given antivenom if skeletal muscle paralysis is to be overcome.

摘要

将普通虎蛇(盾鼻蛇属)毒液以0.25致死剂量(LD)至20 LD的剂量通过实验注射给犬类。注射亚致死(亚麻痹)剂量后,溶血和肌酸激酶值迅速升高,但仅当给犬类注射10 LD或更高剂量的毒液时,血液凝固时间才会延长且血液变得无法凝固。溶血虽然毒性阈值较低,但并不严重,不应极大地影响毒液的致死性。凝血障碍表明犬类已受到致命毒液侵害,若要克服骨骼肌麻痹,需要注射抗蛇毒血清。

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