Moscona R R, Bergman R, Friedman-Birnbaum R
Department of Plastic Surgery, Rambam Medical Center, Haifa, Israel.
Plast Reconstr Surg. 1993 Aug;92(2):331-4. doi: 10.1097/00006534-199308000-00021.
We describe a patient who, 2 1/2 years after injection with Zyderm I collagen, developed large erythematous indurated nodules and plaques at the facial injection sites. This occurred despite a prior negative skin test with the injectable material. Histopathologically, a sarcoid-like foreign-body reaction was present in the dermis and subcutaneous fat and muscles. Retesting with Zyderm I collagen on the forearm produced a positive reaction that showed, histologically, a sarcoid-like reaction similar to that which was found in the face. Various modes of therapy have failed to clear the facial lesions and disfigurement.
我们描述了一名患者，在注射Zy derm I胶原蛋白2年半后，面部注射部位出现了大的红斑性硬结结节和斑块。尽管之前对注射材料进行的皮肤试验呈阴性，但仍出现了这种情况。组织病理学检查显示，真皮、皮下脂肪和肌肉中存在类肉瘤样异物反应。在前臂再次用Zy derm I胶原蛋白进行测试产生了阳性反应，组织学检查显示出与面部发现的类似的类肉瘤样反应。各种治疗方法均未能消除面部病变和畸形。
