Drury J K, McKay A J, Hutchison J S, Joffe S N
Lancet. 1978 Oct 7;2(8093):749-50. doi: 10.1016/s0140-6736(78)92643-0.
Of 50 patients with a perforated duodenal ulcer treated with simple suture closure, 36 (72%) had symptoms before the perforation for a mean period of 9.9 years. 24 of the 36 (66.6%) acquired further symptoms or complications at 1--48 months (mean 11 months) after the operation, whereas only 2 of the 14 patients (14%) who were symptom-free preoperatively had further complications. At follow-up 48% of the patients were still free of symptoms. Simple suture closure with a "wait and see" policy remains the treatment of choice, and a prospective clinical study to evaluate definitive emergency surgery for duodenal ulcer has been cancelled.
在50例采用单纯缝合关闭术治疗的十二指肠溃疡穿孔患者中，36例（72%）在穿孔前有症状，平均病程为9.9年。这36例患者中有24例（66.6%）在术后1至48个月（平均11个月）出现了进一步的症状或并发症，而术前无症状的14例患者中只有2例（14%）出现了进一步的并发症。随访时，48%的患者仍无症状。采用“观察等待”策略的单纯缝合关闭术仍是首选治疗方法，一项评估十二指肠溃疡确定性急诊手术的前瞻性临床研究已被取消。
