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NF-ATp：一种协调诱导多种细胞因子基因表达所需的转录因子。

NF-ATp: a transcription factor required for the co-ordinate induction of several cytokine genes.

作者信息

Rao A

机构信息

Dept of Pathology, Harvard Medical School, Boston, MA.

出版信息

Immunol Today. 1994 Jun;15(6):274-81. doi: 10.1016/0167-5699(94)90007-8.

DOI:10.1016/0167-5699(94)90007-8
PMID:8068174
Abstract

The transcription factor NF-ATp is a target in activated T cells for the calcium-regulated phosphatase calcineurin, and is therefore a secondary target for the immunosuppressive drugs cyclosporin A and FK506. Here, Anjana Rao describes how NF-ATp cooperates with Fos- and Jun-family proteins to mediate transcription of the interleukin 2 gene, and how it may participate in the calcium-dependent transcription of other cytokine genes in several types of immune-system cells.

摘要

转录因子NF-ATp是活化T细胞中钙调节磷酸酶钙调神经磷酸酶的作用靶点，因此也是免疫抑制药物环孢菌素A和FK506的次要作用靶点。在此，安贾娜·拉奥描述了NF-ATp如何与Fos和Jun家族蛋白协同作用以介导白细胞介素2基因的转录，以及它如何可能参与几种免疫系统细胞中其他细胞因子基因的钙依赖性转录。

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