Pieri E, Orsilles M A
Laboratorio de Immunología, Hospital Rawson, Córdoba, Argentina.
APMIS. 1994 Jun;102(6):427-31. doi: 10.1111/j.1699-0463.1994.tb04894.x.
Superoxide (O2.-) production by polymorphonuclear neutrophils (PMN) was assessed in 17 subjects with asymptomatic infection (AI), 16 patients with acquired immunodeficiency syndrome (AIDS), and 12 healthy normal subjects. The effect of patients' serum on the oxidative activity of normal and patients' PMN was also investigated. The O2.- production, nonstimulated and stimulated with zymosan particles in the presence of normal serum, was similar to that of normal controls in both groups of patients. The serum from 11 out of the 17 AI subjects (65%) induced an increase in the stimulated O2.- production in normal and patients' PMN, while the serum from 8 out of the 16 AIDS patients (50%) induced a diminution. These effects did not appear to be related to complement C3 and circulating immune complex levels, but suggest that PMN of HIV-seropositive patients do not present an intrinsic dysfunction and that the impact of serum factor(s) affects the normal oxidative activity of these cells depending on the stage of infection.
在17名无症状感染者（AI）、16名获得性免疫缺陷综合征（AIDS）患者和12名健康正常受试者中评估了多形核中性粒细胞（PMN）产生超氧化物（O2.-）的情况。还研究了患者血清对正常和患者PMN氧化活性的影响。在正常血清存在下，两组患者未刺激和用酵母聚糖颗粒刺激后的O2.-产生与正常对照组相似。17名AI受试者中的11名（65%）的血清可诱导正常和患者PMN中刺激后的O2.-产生增加，而16名AIDS患者中的8名（50%）的血清则导致其减少。这些影响似乎与补体C3和循环免疫复合物水平无关，但表明HIV血清阳性患者的PMN不存在内在功能障碍，并且血清因子的影响取决于感染阶段，会影响这些细胞的正常氧化活性。
