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冠状动脉闭塞终止再灌注心律失常。

Termination of reperfusion arrhythmia by coronary artery occlusion.

作者信息

Grech E D, Ramsdale D R

机构信息

Department of Cardiology, Cardiothoracic Centre, Liverpool.

出版信息

Br Heart J. 1994 Jul;72(1):94-5. doi: 10.1136/hrt.72.1.94.

DOI:10.1136/hrt.72.1.94
PMID:8068480
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1025434/
Abstract

Reperfusion arrhythmias may be a cause of sudden death in acute myocardial infarction. A patient underwent successful coronary artery recanalisation by primary percutaneous transluminal coronary angioplasty (PTCA) for acute myocardial infarction. In this patient an idioventricular rhythm with a severe haemodynamic effect developed within one minute of deflation of the PTCA balloon. Sinus rhythm was immediately restored by reinflating the balloon and thus reinterrupting the supply of oxygenated blood. This suggests that reperfusion with consequent reoxygenation is a primary factor in arrhythmogenesis.

摘要

再灌注心律失常可能是急性心肌梗死患者猝死的原因之一。一名患者因急性心肌梗死接受了直接经皮冠状动脉腔内血管成形术(PTCA),成功实现了冠状动脉再通。在该患者中,PTCA球囊放气后一分钟内出现了具有严重血流动力学影响的室性自主心律。通过重新充盈球囊,从而再次中断含氧血液供应,窦性心律立即恢复。这表明再灌注及随之而来的再氧合是心律失常发生的主要因素。

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本文引用的文献

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Free-radical generation during angioplasty reperfusion for acute myocardial infarction.急性心肌梗死血管成形术再灌注期间的自由基生成
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Instantaneous and delayed ventricular arrhythmias after reperfusion of acutely ischemic myocardium: evidence for multiple mechanisms.急性缺血心肌再灌注后即刻及延迟性室性心律失常:多种机制的证据
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Reperfusion arrhythmia: a marker of restoration of antegrade flow during intracoronary thrombolysis for acute myocardial infarction.再灌注心律失常:急性心肌梗死冠状动脉内溶栓期间顺行血流恢复的一个标志。
Am Heart J. 1983 Jan;105(1):26-32. doi: 10.1016/0002-8703(83)90274-0.
4
Five hundred patients with myocardial infarction monitored within one hour of symptoms.500例心肌梗死患者在症状出现1小时内接受了监测。
Br Med J (Clin Res Ed). 1983 Apr 30;286(6375):1405-8. doi: 10.1136/bmj.286.6375.1405.
5
Reperfusion-induced arrhythmias and oxygen-derived free radicals. Studies with "anti-free radical" interventions and a free radical-generating system in the isolated perfused rat heart.再灌注诱导的心律失常与氧衍生自由基。在离体灌注大鼠心脏中使用“抗自由基”干预措施及自由基生成系统的研究。
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6
Proarrhythmic effects of an oxygen-derived free radical generating system on action potentials recorded from guinea pig ventricular myocardium: a possible cause of reperfusion-induced arrhythmias.氧衍生自由基生成系统对豚鼠心室肌记录的动作电位的促心律失常作用:再灌注诱导心律失常的一个可能原因。
Circ Res. 1987 Jul;61(1):50-4. doi: 10.1161/01.res.61.1.50.