Smith S, Scott L, Hosid S
Department of Obstetrics and Gynecology, Sinai Hospital of Baltimore, Maryland 21215.
J Assist Reprod Genet. 1993 Oct;10(7):478-80. doi: 10.1007/BF01212937.
We present a case of heterotopic pregnancy occurring after ET of pronuclear-stage embryos. This case demonstrates that pronuclear embryos have a good implantation potential and suggests that the potentially adverse effect of high follicular-phase serum progesterone levels on endometrial development might be offset by early ET of pronuclear embryos. This, however, is speculative and deserving of formal scientific evaluation. Finally, we are reminded that heterotopic pregnancy complicates 1 to 3% of IVF-ET pregnancies and that, even with a high index of suspicion, most heterotopic pregnancies are diagnosed after rupture. All assisted reproductive programs should be reminded frequently that ectopic and heterotopic pregnancies do occur and can lead to serious consequences if left undetected.
我们报告一例原核期胚胎移植后发生的异位妊娠病例。该病例表明原核胚胎具有良好的着床潜力，并提示高卵泡期血清孕酮水平对子宫内膜发育的潜在不利影响可能会被原核胚胎的早期移植所抵消。然而，这只是推测，值得进行正式的科学评估。最后，我们要提醒的是，异位妊娠使1%至3%的体外受精-胚胎移植妊娠复杂化，而且，即使高度怀疑，大多数异位妊娠也是在破裂后才被诊断出来的。所有辅助生殖项目都应经常得到提醒，异位妊娠和异时妊娠确实会发生，如果未被发现可能会导致严重后果。
