Quinn P, Stone B A, Marrs R P
Institute for Reproductive Research, Hospital of the Good Samaritan, Los Angeles, California.
Fertil Steril. 1990 Jan;53(1):168-70. doi: 10.1016/s0015-0282(16)53236-1.
We have demonstrated that the replacement of pronuclear stage human embryos on the day after insemination in IVF-ET results in a pregnancy rate as good as, if not better than, the rate after ET on day 2. The pregnancy rate appears to be influenced by the culture environment used for the gametes. We would recommend that ET be undertaken as soon as possible after insemination on day 1 so that if suboptimal culture conditions are present, they do not have sufficient time to affect the viability of the embryos and reduce the subsequent chance of pregnancy after replacement. If culture conditions have been optimized there is no difference in pregnancy rate after embryo transfer on day 1 or day 2 and one can then replace embryos on either day and expect the pregnancy rate obtained in either case to be similar.
我们已经证明，在体外受精-胚胎移植（IVF-ET）中，授精后第二天替换原核期人类胚胎所获得的妊娠率，即便不比第二天进行胚胎移植（ET）后的妊娠率更高，至少也与之相当。妊娠率似乎受配子培养环境的影响。我们建议在授精后第一天尽快进行胚胎移植，这样一来，如果存在欠佳的培养条件，这些条件也没有足够时间影响胚胎的活力并降低移植后随后的妊娠几率。如果培养条件已得到优化，那么第一天或第二天进行胚胎移植后的妊娠率并无差异，因而可以在任意一天替换胚胎，并预期在这两种情况下所获得的妊娠率相近。
