Ohya T
Faculty of Pharmaceutical Sciences, Josai University, Saitama, Japan.
Biol Pharm Bull. 1994 Apr;17(4):554-6. doi: 10.1248/bpb.17.554.
The reaction of malondialdehyde (MDA) with alpha-N-acetyl-histidine (Ac-His) in the presence of alkanal was investigated. MDA alone did not react with Ac-His but when alkanal was present, a reaction took place. A similar result was obtained for the reaction of MDA with imidazole in the presence of alkanal. In addition, the structure of the product obtained following the reaction of MDA with imidazole in the presence of acetaldehyde was investigated. The structure of this product was identified as a 1:1:1 adduct of MDA, acetaldehyde and imidazole (2).
研究了丙二醛（MDA）在链烷醛存在下与α-N-乙酰组氨酸（Ac-His）的反应。单独的MDA不与Ac-His反应，但当存在链烷醛时，会发生反应。对于MDA在链烷醛存在下与咪唑的反应也得到了类似的结果。此外，还研究了MDA在乙醛存在下与咪唑反应后所得产物的结构。该产物的结构被鉴定为MDA、乙醛和咪唑的1:1:1加合物（2）。
