Geiduschek J M, Haberkern C M, McLaughlin J F, Jacobson L E, Hays R M, Roberts T S
Department of Anesthesiology, University of Washington School of Medicine, Children's Hospital and Medical Center, Seattle 98105.
Can J Anaesth. 1994 Jun;41(6):492-6. doi: 10.1007/BF03011543.
Selective dorsal rhizotomy (SDR) is a neurosurgical procedure used for treating lower extremity spasticity in patients with cerebral palsy. The purpose of this paper is to present a review of our institution's first three years' experience with postoperative pain and spasticity management in patients who have undergone SDR. The medical records of the 55 patients who had an SDR during the study period were reviewed. The basis of postoperative analgesia was morphine, with the majority of patients receiving continuous morphine infusions (20-40 micrograms.kg-1.hr-1 (n = 49), 60 micrograms.kg-1.hr-1 (n = 1)). Four patients used a patient-controlled delivery system. One patient had successful analgesia with epidural morphine. Ketorolac (1 mg.kg-1 i.v. loading dose followed by 0.5 mg.kg-1 i.v. every six hr for 48 hr) was used as an adjunct to morphine in six patients. For management of postoperative muscle spasm, an intravenous benzodiazepine was used (diazepam 0.1 mg.kg-1 (n = 2), or midazolam infusion 10-30 micrograms.kg-1.hr-1 (n = 51)). All patients were cared for on a ward where nurses were familiar with the use of continuous opioid and benzodiazepine infusions. All patients received continuous cardiorespiratory monitoring as well as frequent nursing assessment. There were no episodes of postoperative apnoea or excessive sedation. We have found the use of continuous infusions of morphine and midazolam, along with adjunct ketorolac, to be effective in treating postoperative pain and muscle spasms following SDR.
选择性脊神经后根切断术(SDR)是一种用于治疗脑瘫患者下肢痉挛的神经外科手术。本文旨在回顾我院对接受SDR手术患者术后疼痛和痉挛管理的头三年经验。回顾了研究期间接受SDR手术的55例患者的病历。术后镇痛的基础药物是吗啡,大多数患者接受持续吗啡输注(20 - 40微克·千克⁻¹·小时⁻¹(n = 49),60微克·千克⁻¹·小时⁻¹(n = 1))。4例患者使用了患者自控给药系统。1例患者使用硬膜外吗啡镇痛成功。6例患者使用酮咯酸(静脉注射负荷剂量1毫克·千克⁻¹,随后每6小时静脉注射0.5毫克·千克⁻¹,持续48小时)作为吗啡的辅助药物。对于术后肌肉痉挛的管理,使用了静脉注射苯二氮䓬类药物(地西泮0.1毫克·千克⁻¹(n = 2),或咪达唑仑输注10 - 30微克·千克⁻¹·小时⁻¹(n = 51))。所有患者均在病房接受护理,护士熟悉持续阿片类药物和苯二氮䓬类药物输注的使用。所有患者均接受持续心肺监测以及频繁的护理评估。未发生术后呼吸暂停或过度镇静事件。我们发现持续输注吗啡和咪达唑仑,以及辅助使用酮咯酸,在治疗SDR术后疼痛和肌肉痉挛方面是有效的。