Haugen M A, Kjeldsen-Kragh J, Førre O
Oslo Sanitetsforening Rheumatism Hospital, Norway.
Clin Exp Rheumatol. 1994 May-Jun;12(3):275-9.
To evaluate the extent of food allergy/intolerance in rheumatoid arthritis, an elemental (hypoallergenic) diet was studied in a controlled, double-blind pilot study. Ten patients were allocated to an experimental group and 7 to a control group. The patients in the experimental group received an elemental diet for 3 weeks, whereas the patients in the control group received a control soup consisting of milk, meat, fish, shellfish, orange, pineapples, tomatoes, peas and flour of wheat and corn. During the 4th week of the study the patients in both groups resumed their regular diet. A significant improvement was found in the number of tender joints (p = 0.04) in the experimental group, whereas improvement was found in the erythrocyte sedimentation rate (ESR) (p = 0.03) and in the thrombocyte count (p = 0.02) in the control group. Three patients in the elemental diet group and 2 patients in the control group improved in all of the measured disease variables during the dietary treatment period. There was no significant difference in disease activity variables between the two groups. These results suggest that some RA patients may respond to the elimination of offending food items. However, the results do not encourage treatment with an elemental diet in unselected RA patients.
为评估类风湿性关节炎患者食物过敏/不耐受的程度，在一项对照双盲试验研究中对要素（低变应原性）饮食进行了研究。10名患者被分配到试验组，7名患者被分配到对照组。试验组患者接受要素饮食3周，而对照组患者接受由牛奶、肉类、鱼类、贝类、橙子、菠萝、西红柿、豌豆以及小麦和玉米面粉组成的对照汤。在研究的第4周，两组患者恢复常规饮食。试验组压痛关节数量有显著改善（p = 0.04），而对照组红细胞沉降率（ESR）（p = 0.03）和血小板计数（p = 0.02）有改善。要素饮食组有3名患者和对照组有2名患者在饮食治疗期间所有测量的疾病变量均有改善。两组之间疾病活动变量无显著差异。这些结果表明，一些类风湿性关节炎患者可能对去除致敏食物有反应。然而，这些结果不支持在未选择的类风湿性关节炎患者中采用要素饮食进行治疗。
