Enamel formation and the effects of fluoride.

The exact biochemical events which result in enamel lesions from excess fluoride ingestion are still unknown. A number of effects of fluoride on enamel organs and on the enamel matrix components of developing teeth are, however, known. These are briefly reviewed, making reference to more recent studies. Two major influences of chronic, low-level fluoride exposure are proposed: fluoride interferes with the processes responsible for the efficient removal of organic matrix components, resulting in protein retention and disorganized enamel crystal formation, or fluoride disrupts the activities of the enamel organ cells which indirectly interferes with normal crystal formation.