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未降解的静脉注射用人免疫球蛋白。

Undegraded human immunoglobulin for intravenous use.

作者信息

Stephan W

出版信息

Vox Sang. 1975;28(6):422-37. doi: 10.1111/j.1423-0410.1975.tb02791.x.

DOI:10.1111/j.1423-0410.1975.tb02791.x
PMID:807036
Abstract

A report is presented on the development and the properties of a nondegraded human immunoglobulin preparation suitable for intravenous administration. Intravenous tolerance is achieved by elimination of anticomplementary activity through modification with beta-propiolactone. The natural antibody characteristics, such as antibody activity, molecular weight, and half-life, are retained. The findings presented open up new perspectives for an extension of the range of indication for intravenous immunoglobulin.

摘要

本文报道了一种适用于静脉注射的未降解人免疫球蛋白制剂的研发及其特性。通过用β-丙内酯进行修饰消除抗补体活性，从而实现静脉耐受性。其天然抗体特性，如抗体活性、分子量和半衰期得以保留。所呈现的研究结果为扩大静脉注射免疫球蛋白的适应证范围开辟了新的前景。

相似文献

1
Undegraded human immunoglobulin for intravenous use.未降解的静脉注射用人免疫球蛋白。
Vox Sang. 1975;28(6):422-37. doi: 10.1111/j.1423-0410.1975.tb02791.x.
2
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Monatsschr Kinderheilkd (1902). 1970 Apr;118(4):123-7.
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Undegraded -globulin for intravenous therapy. A new preparation of immune serum globulin for intravenous administration.静脉注射用未降解γ球蛋白。一种新的静脉注射用免疫血清球蛋白制剂。
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Comparison of in vitro behaviour and in vivo efficacy of two 7S-immunoglobulin preparations for intravenous use.两种静脉用7S免疫球蛋白制剂的体外行为与体内疗效比较。
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Purity, anticomplementary activity, and viral antibody profile of NIG preparations for intravenous and intramuscular use.静脉和肌肉注射用NIG制剂的纯度、抗补体活性及病毒抗体谱。
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Humoral immune status of mongoloid children compared with other congenital defects: quantitative and qualitative aspects of immunoglobulins.
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引用本文的文献

1
Limited Innovations After More Than 65 Years of Immunoglobulin Replacement Therapy: Potential of IgA- and IgM-Enriched Formulations to Prevent Bacterial Respiratory Tract Infections.免疫球蛋白替代疗法超过 65 年后的有限创新：富含 IgA 和 IgM 的制剂预防细菌性呼吸道感染的潜力。
Front Immunol. 2018 Aug 23;9:1925. doi: 10.3389/fimmu.2018.01925. eCollection 2018.
2
Intravenous immunoglobulins: evolution of commercial IVIG preparations.静脉注射免疫球蛋白：市售静脉注射免疫球蛋白制剂的演变
Immunol Allergy Clin North Am. 2008 Nov;28(4):765-78, viii. doi: 10.1016/j.iac.2008.06.002.
3
Basic principles of intravenous immunoglobulin (IVIg) treatment.
静脉注射免疫球蛋白（IVIg）治疗的基本原则。
J Neurol. 2006 Sep;253 Suppl 5:V18-24. doi: 10.1007/s00415-006-5003-1.
4
Multicenter crossover comparison of the safety and efficacy of Intraglobin-F with Gamimune-N, Sandoglobulin, and Gammagard in patients with primary immunodeficiency diseases.Intraglobin-F与Gamimune-N、Sandoglobulin和Gammagard在原发性免疫缺陷疾病患者中的安全性和有效性的多中心交叉比较。
J Clin Immunol. 1997 Jan;17(1):21-8. doi: 10.1023/a:1027380210989.
5
Reduced efficacy of sulfitolysed intravenous immunoglobulin.
Eur J Clin Microbiol. 1984 Feb;3(1):47. doi: 10.1007/BF02032820.
6
[Problems of intravenous gammaglobulin therapy (author's transl)].静脉注射丙种球蛋白治疗的问题（作者译）
Klin Wochenschr. 1980 Aug 15;58(16):797-809. doi: 10.1007/BF01491100.
7
Some side effects of intravenous 7S-immunoglobulins are due to immune complexes and can be prevented by 5S-immunoglobulin given prior to 7S treatment.静脉注射7S免疫球蛋白的一些副作用是由免疫复合物引起的，在7S治疗前给予5S免疫球蛋白可以预防这些副作用。
Clin Exp Immunol. 1986 Jan;63(1):258-9.
8
[Prevention of gram-negative and gram-positive infections using 3 intravenous immunoglobulin preparations and therapy of experimental polymicrobial burn infection using intravenous Pseudomonas immunoglobulin G and ciprofloxacin in an animal model].[使用3种静脉注射免疫球蛋白制剂预防革兰氏阴性和革兰氏阳性感染以及在动物模型中使用静脉注射铜绿假单胞菌免疫球蛋白G和环丙沙星治疗实验性多微生物烧伤感染]
Infection. 1987 Jan-Feb;15(1):60-8. doi: 10.1007/BF01646125.
9
Antipyretic activity of a human immunoglobulin preparation for intravenous use in an experimental model of fever in rabbits.一种静脉用人免疫球蛋白制剂在兔发热实验模型中的解热活性。
Infect Immun. 1987 Mar;55(3):547-54. doi: 10.1128/iai.55.3.547-554.1987.
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Inactivation of HIV in plasma derivatives by beta-propiolactone and UV irradiation.通过β-丙内酯和紫外线照射使血浆衍生物中的HIV失活。
Infection. 1987;15(5):367-9. doi: 10.1007/BF01647745.