Cummings D M, Brunjes P C
Neuroscience Program, University of Virginia, Charlottesville 22903.
Exp Neurol. 1994 Jul;128(1):124-8. doi: 10.1006/exnr.1994.1119.
Surgical closure of an external naris reduces airflow through one side of the nasal cavity. Previous studies using [3H]thymidine autoradiography have demonstrated that rats subjected to the procedure on Postnatal Day 1 (P1) exhibit reduced cellular proliferation in the olfactory mucosa by P30. We investigated cell production at earlier ages to determine (a) when the effect first emerges, and (b) whether septal, dorsal, and lateral regions of the nasal cavity responded similarly. Both short (2-h) and long (30-day) survival groups were tested. Results from the first group indicate that changes in proliferation emerge between P10 and P20, and that the septum is more affected than other regions of the nasal cavity. No differences were observed in the long survival groups, perhaps due to changes in patterns of cell production or death.
外科封闭一侧鼻孔会减少通过鼻腔一侧的气流。先前使用[3H]胸腺嘧啶核苷放射自显影术的研究表明，在出生后第1天（P1）接受该手术的大鼠，到出生后第30天（P30）时嗅黏膜中的细胞增殖减少。我们研究了更早年龄段的细胞生成情况，以确定（a）这种影响何时首次出现，以及（b）鼻腔的鼻中隔、背侧和外侧区域的反应是否相似。对短期（2小时）和长期（30天）存活组都进行了测试。第一组的结果表明，增殖变化出现在P10到P20之间，且鼻中隔比鼻腔的其他区域受影响更大。长期存活组未观察到差异，这可能是由于细胞生成或死亡模式的变化所致。
