Scott D
Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester, United Kingdom.
IARC Sci Publ. 1993(127):275-86.
In 17 of 50 cytogenetic studies (on chromosomal aberrations, micronucleus formation and sister chromatid exchange) in peripheral blood lymphocytes from a total of 667 workers in industries in which there is exposure to styrene, significant increases in the frequency of chromosomal damage have been reported when compared with unexposed controls. The positive or negative outcome of these studies is, however, unrelated to the extent of exposure to styrene. Furthermore, in the 17 investigations in which positive results were found, there is no convincing evidence of a positive dose-response relationship, in spite of the wide ranges of exposure and different methods of measurement. There are also serious discrepancies between findings on the chromosomal damaging effects of styrene in human lymphocytes in vitro and the types of damage reported in exposed workers. The findings are not consistent with the interpretation that styrene is responsible for the observed effects in workers. Several other chemicals identified in the environment of styrene workers have been reported to induce chromosomal damage in vitro and/or in vivo.
在对667名接触苯乙烯行业工人外周血淋巴细胞进行的50项细胞遗传学研究（关于染色体畸变、微核形成和姐妹染色单体交换）中，有17项研究报告称，与未接触的对照组相比，染色体损伤频率显著增加。然而，这些研究的阳性或阴性结果与苯乙烯接触程度无关。此外，在发现阳性结果的17项调查中，尽管接触范围广泛且测量方法不同，但没有令人信服的证据表明存在阳性剂量反应关系。在体外对人淋巴细胞中苯乙烯的染色体损伤作用的研究结果与接触工人报告的损伤类型之间也存在严重差异。这些结果与苯乙烯是导致工人中观察到的效应的原因这一解释不一致。据报道，在苯乙烯工人的工作环境中发现的其他几种化学物质可在体外和/或体内诱导染色体损伤。
