Maraki S, Barbounakis E, Chatzinikolaou I, Anatoliotakis N, Plataki M, Tselentis Y, Samonis G
The University of Crete, Division of Medicine, Heraklion, Crete, Greece.
Chemotherapy. 1998 Nov-Dec;44(6):405-8. doi: 10.1159/000007151.
Crl:CD1(ICR) BR mice were fed chow containing Candida albicans or regular chow. Both groups were subsequently given either antibiotics or normal saline. Stool cultures were performed before, at the end of treatment and 1 week after treatment, to determine the effect on the stool yeast concentration. Candida-colonized mice treated with cefepime, cefixime or ceftibuten had higher (however not significantly) counts of the yeast in their stools than control Candida-fed mice treated with saline. A group of Candida-fed mice were treated with ceftriaxone, which is known to increase the yeast stool concentration significantly and served as positive control. Mice fed regular chow and treated with the study drugs or saline did not have any yeasts in their stools. Dissemination of Candida did not occur.
CD1（ICR）BR小鼠分别喂食含有白色念珠菌的饲料或普通饲料。随后两组小鼠均给予抗生素或生理盐水。在治疗前、治疗结束时及治疗后1周进行粪便培养，以确定对粪便中酵母浓度的影响。用头孢吡肟、头孢克肟或头孢布烯治疗的白色念珠菌定植小鼠粪便中的酵母计数高于用生理盐水治疗的对照白色念珠菌喂养小鼠（然而差异不显著）。一组白色念珠菌喂养小鼠用头孢曲松治疗，已知头孢曲松可显著增加粪便中酵母浓度，作为阳性对照。喂食普通饲料并用研究药物或生理盐水治疗的小鼠粪便中没有任何酵母。未发生白色念珠菌的播散。
