Samonis G, Maraki S, Leventakos K, Spanaki A M, Kateifidis A, Galanakis E, Tselentis Y, Falagas M E, Mantadakis E
Department of Medicine, University Hospital of Heraklion, Heraklion, Crete, Greece.
Med Mycol. 2006 May;44(3):233-5. doi: 10.1080/13693780500395225.
We evaluated the effect of three carbapenems on gut colonization of mice by Candida albicans. A total of 150 Crl:CD1 (ICR) BR mice were fed chow containing C. albicans or regular chow. Both groups were subsequently treated either with one carbapenem or with normal saline for 10 days. Stool cultures to determine colonization by C. albicans were performed immediately before, at the end, and one week after the end of treatment. Candida-colonized mice that received carbapenems had substantially higher C. albicans concentrations than control animals fed C. albicans, especially if they received ertapenem. Mice fed regular chow and treated with the study antibiotics or saline did not have Candida in their stools. Candida was not detected in the internal organs of any group of mice.
我们评估了三种碳青霉烯类药物对白色念珠菌在小鼠肠道定植的影响。总共150只Crl:CD1 (ICR) BR小鼠被喂食含有白色念珠菌的食物或普通食物。随后，两组小鼠分别接受一种碳青霉烯类药物或生理盐水治疗10天。在治疗前、治疗结束时以及治疗结束后一周立即进行粪便培养以确定白色念珠菌的定植情况。接受碳青霉烯类药物治疗的念珠菌定植小鼠体内白色念珠菌浓度显著高于喂食白色念珠菌的对照动物，尤其是接受厄他培南治疗的小鼠。喂食普通食物并接受研究用抗生素或生理盐水治疗的小鼠粪便中未检测到念珠菌。任何一组小鼠的内脏器官中均未检测到念珠菌。
