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在分泌性腹泻大鼠模型中评估不同溶质含量对口服补液溶液疗效的影响。

Evaluation of the effects of varying solute content on the efficacy of oral rehydration solutions in a rat model of secretory diarrhoea.

作者信息

Pillai G V, Brueton M J, Burston D, Sandhu B K

机构信息

Department of Child Health, Chelsea and Westminster Hospital, London, England.

出版信息

J Pediatr Gastroenterol Nutr. 1994 May;18(4):457-60. doi: 10.1097/00005176-199405000-00009.

DOI:10.1097/00005176-199405000-00009
PMID:8071782
Abstract

A series of in vivo steady-state perfusion studies in cholera toxin-induced secreting rat intestine were carried out to investigate net water, sodium, and potassium absorption and water influx and efflux from a range of oral rehydration solutions (ORSs) in which the glucose content had been partially replaced by amino acids or food supplements and the sodium content had been reduced to 60 mM. The reference solution used was the World Health Organization formula. There was a significant correlation between the osmolality of the ORS and the net water absorption (r = -0.911; p < 0.02). The greatest net water absorption occurred using comminuted chicken- and tapioca-supplemented ORS.

摘要

进行了一系列霍乱毒素诱导的分泌性大鼠肠道的体内稳态灌注研究,以研究一系列口服补液溶液(ORS)的净水分、钠和钾吸收以及水分流入和流出情况,这些ORS中葡萄糖含量已部分被氨基酸或食物补充剂替代,且钠含量已降至60 mM。所使用的参考溶液为世界卫生组织配方。ORS的渗透压与净水分吸收之间存在显著相关性(r = -0.911;p < 0.02)。使用添加了粉碎鸡肉和木薯的ORS时,净水分吸收最大。

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