Quin J W, Lascelles A K
Aust J Exp Biol Med Sci. 1975 Feb;53(1):1-9. doi: 10.1038/icb.1975.1.
The concentration and output of lymphocytes in lymph from the popliteal node in sheep were varied by antigenic stimulation of the lymph node and by intravenous administration of bovine anti-lymphocyte serum (ALS). The 4-5-fold increase in output and concentration of lymphocytes in lymph following antigenic stimulation of the node was accompanied by a 25-35% increase in the concentration of total protein and albumin. The above changes were not observed in afferent lymph draining the site of antigen injection. There was a 75-80% decrease in concentration of lymphocytes in lymph from the unstimulated popliteal lymph node following the administration of ALS and this was accompanied by decreases of 10-35% in the concentration of albumin and immunoglobulin. Essentially the same changes were observed when ALS was administered 6 days after antigenic stimulation of the node. Administration of ALS to sheep with cannulated intestinal lymphatic ducts was followed by a 75-80% reduction in lymphocyte concentration and in decreases ranging from 12-50% in the concentration of albumin, IgM and IgG-2. It is suggested that a significant loss of plasma protein is associated with the migration of lymphocytes between the endothelial cells of the post-capillary venules in lymph nodes.
通过对绵羊腘淋巴结进行抗原刺激以及静脉注射牛抗淋巴细胞血清（ALS），可改变来自该淋巴结的淋巴中淋巴细胞的浓度和输出量。对淋巴结进行抗原刺激后，淋巴中淋巴细胞的输出量和浓度增加了4至5倍，同时总蛋白和白蛋白的浓度增加了25%至35%。在引流抗原注射部位的输入淋巴中未观察到上述变化。注射ALS后，未受刺激的腘淋巴结淋巴中淋巴细胞的浓度降低了75%至80%，同时白蛋白和免疫球蛋白的浓度降低了10%至35%。在对淋巴结进行抗原刺激6天后注射ALS，观察到的变化基本相同。对具有插管肠淋巴管的绵羊注射ALS后，淋巴细胞浓度降低了75%至80%，白蛋白、IgM和IgG - 2的浓度降低了12%至50%。提示血浆蛋白的显著丢失与淋巴细胞在淋巴结毛细血管后微静脉内皮细胞之间的迁移有关。
