Beh K J
Aust J Exp Biol Med Sci. 1977 Jun;55(3):263-74. doi: 10.1038/icb.1977.21.
The origin of IgA-containing cells in sheep intestinal lymph was determined by antigenically stimulating a mesenteric lymph node and by studying afferent intestinal lymph. Since antigenic stimulation of the node resulted almost exclusively in the appearance of IgG1 antibody-containing cells, it was proposed that IgA-containing cells are normally produced either in the Peyer's patches or lamina propria of the intestine. These conclusions were supported by studying lymph obtained by cannulation of a lymphatic duct afferent to the mesenteric lymph nodes. Study of the cells in afferent lymph revealed the presence of a significant population of IgA-containing blast cells. This was convincing evidence that the IgA-containing cells normally found in intestinal lymph originate from sites in the intestine.
通过对肠系膜淋巴结进行抗原刺激并研究传入肠淋巴，确定了绵羊肠道淋巴中含IgA细胞的起源。由于对该淋巴结的抗原刺激几乎只导致了含IgG1抗体细胞的出现，因此有人提出，含IgA细胞通常在肠道的派尔集合淋巴结或固有层中产生。通过研究经肠系膜淋巴结传入淋巴管插管获取的淋巴，这些结论得到了支持。对传入淋巴中的细胞研究发现，存在大量含IgA的母细胞。这是令人信服的证据，表明在肠道淋巴中正常发现的含IgA细胞起源于肠道中的部位。
