Komatani A, Akutsu T, Yamaguchi K
Department of Radiology, Yamagata University School of Medicine.
Kaku Igaku. 1994 Jun;31(6):637-41.
Single photon emission computed tomography (SPECT) with 133Xe gas inhalation method enables measurement of regional cerebral blood flow (rCBF) quantitatively. But this method is inferior to the method with 99mTc-HMPAO or 123I-IMP in the quality of images. Efficient administration of 133Xe gas more than usual is supposed to improve quality of SPECT images. In this study we designed bolus inhalation method, a new method to efficiently administer 133Xe gas of usual dose (1,850 MBq), and examined its fundamental aspects and clinical feasibility. The method was initiated by bolus administration of 133Xe gas synchronously in inspiration phase via a small tube connected to a mouthpiece and was followed by steady breathing of the gas in a closed circuit with a spiro-bag. Introduction of this method provided almost twofold increase in count ratio at the head in comparison with a conventional inhalation method. Consequently, considerable improvement in the quality of rCBF images was achieved by optimization of a reconstruction filter of SPECT.
采用133Xe气体吸入法的单光子发射计算机断层扫描（SPECT）能够定量测量局部脑血流量（rCBF）。但该方法在图像质量方面不如使用99mTc-HMPAO或123I-IMP的方法。比通常更有效地给予133Xe气体有望提高SPECT图像的质量。在本研究中，我们设计了团注吸入法，这是一种有效给予常规剂量（1850MBq）133Xe气体的新方法，并研究了其基本特性和临床可行性。该方法通过在吸气阶段经由连接到咬嘴的小管同步团注给予133Xe气体启动，随后在带有呼吸袋的封闭回路中稳定呼吸该气体。与传统吸入法相比，引入该方法使头部的计数率增加了近两倍。因此，通过优化SPECT的重建滤波器，rCBF图像的质量得到了显著改善。
