Smith M A, Perry G
Division of Neuropathology, Case Western Reserve University, Cleveland, OH 44106-4901.
Med Hypotheses. 1994 Apr;42(4):277-9. doi: 10.1016/0306-9877(94)90132-5.
Alzheimer disease is typified by the accumulation of protein and neuronal death. We propose that neuronal death creates a proteolytic imbalance that generates the pathological lesions. Our hypothesis explains the morphology and topographic distribution of neuritic plaques and neurofibrillary tangles.
阿尔茨海默病的典型特征是蛋白质的积累和神经元死亡。我们提出，神经元死亡会造成蛋白水解失衡，进而产生病理性病变。我们的假说解释了神经炎性斑块和神经原纤维缠结的形态及拓扑分布。
