Cline M S
Allegheny General Hospital, Pittsburgh.
Postgrad Med. 1994 Sep 1;96(3):124-6. doi: 10.1080/00325481.1994.11945897.
Methemoglobinemia should always be considered in the differential diagnosis of cyanosis in patients with normal arterial oxygen tension. Cyanosis that is brownish and not relieved by oxygen administration should lead to consideration of the diagnosis. A normal or elevated PaO2 value further suggests the presence of methemoglobinemia. Mild cases can be treated by removing the offending agent. In more severe cases, intravenous methylene blue and, if necessary, packed red cells or exchange transfusions may be given.
在动脉血氧张力正常的患者出现发绀的鉴别诊断中，应始终考虑高铁血红蛋白血症。呈褐色且吸氧后不缓解的发绀应促使考虑该诊断。正常或升高的动脉血氧分压值进一步提示存在高铁血红蛋白血症。轻度病例可通过去除致病因素进行治疗。在更严重的病例中，可静脉给予亚甲蓝，必要时可输注浓缩红细胞或进行换血治疗。
