Akgür F M, Kilinç K, Tanyel F C, Büyükpamukçu N, Hiçsönmez A
Department of Pediatric Surgery, Hacettepe University, Medical Faculty, Ankara, Turkey.
Urology. 1994 Sep;44(3):413-8. doi: 10.1016/s0090-4295(94)80105-3.
An experimental study has been conducted to investigate testicular blood flow alterations through acute biochemical changes during unilateral testicular torsion and detorsion.
One hundred twenty male albino rats were divided into 12 groups, each containing 10 rats. One group served to determine basal values of biochemical parameters, 4 groups were subjected to varying periods of unilateral testicular torsion (3, 6, 12, and 24 hours, respectively), 3 groups were subjected to detorsion following varying periods of torsion (6, 12, and 24 hours, respectively), and 4 groups underwent sham operations as controls. Levels of lactic acid, hypoxanthine, and lipid peroxidation products were determined in testicular tissues.
Values of these 3 parameters obtained from sham operation control groups did not differ significantly from basal values (p > 0.05). All 3 parameters were increased significantly in both ipsilateral torted and contralateral nontorted testes after unilateral testicular torsion when compared with basal values (p < 0.05). Detorsion did not cause significant changes in levels of lipid peroxidation products in both ipsilateral torted and contralateral nontorted testes when compared with values obtained after torsion (p > 0.05).
Ipsilateral testicular torsion causes a decrease not only in the ipsilateral torted but also in the contralateral nontorted testicular perfusion. The clues of reperfusion injury do not become evident following detorsion of testicular torsion lasting more than 6 hours.
进行了一项实验研究，以探讨单侧睾丸扭转和扭转复位过程中急性生化变化引起的睾丸血流改变。
将120只雄性白化大鼠分为12组，每组10只。一组用于确定生化参数的基础值，4组分别接受不同时长的单侧睾丸扭转（分别为3、6、12和24小时），3组在不同时长的扭转后进行扭转复位（分别为6、12和24小时），4组进行假手术作为对照。测定睾丸组织中乳酸、次黄嘌呤和脂质过氧化产物的水平。
假手术对照组获得的这3个参数值与基础值相比无显著差异（p>0.05）。与基础值相比，单侧睾丸扭转后同侧扭转睾丸和对侧未扭转睾丸的所有3个参数均显著升高（p<0.05）。与扭转后获得的值相比，扭转复位并未导致同侧扭转睾丸和对侧未扭转睾丸中脂质过氧化产物水平的显著变化（p>0.05）。
同侧睾丸扭转不仅会导致同侧扭转睾丸灌注减少，还会导致对侧未扭转睾丸灌注减少。持续超过6小时的睾丸扭转复位后，再灌注损伤的线索并不明显。
