[庆大霉素对大鼠肾脏溶酶体的作用]
[The effect of gentamicin on rat kidney lysosomes].
作者信息
Leseur J P, Fillastre J E, Vaillant R
出版信息
C R Acad Hebd Seances Acad Sci D. 1975 Apr 14;280(14):1693-6.
PMID:807359
Abstract
The in vitro action of gentamicin on kidney lysosomes gives rise to an increase in free acid phosphatase activity compared with total activity which points to a modification in the lysosomal membrane. These effects are more marked in pregnant rats, probably due to progesterone, but reduced in vitro by chloroquine.
摘要
庆大霉素对肾溶酶体的体外作用导致游离酸性磷酸酶活性相对于总活性增加，这表明溶酶体膜发生了改变。这些效应在妊娠大鼠中更为明显，可能是由于孕酮所致，但在体外可被氯喹降低。
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