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[使用计算机模拟模型研究慢性血液透析单位患者丙型肝炎流行过程中输血因素的重要性]

[The importance of the blood transfusion factor in the epidemic process in hepatitis C in the patients of chronic hemodialysis units studied using a computer simulation model].

作者信息

Savin E A, Kuzin S N, Blinov V M, Loparev V N, Sukhanova L L, Gol'tsov V A, Ershova G N, Viazov S O, Shakhgil'dian I V

出版信息

Vopr Virusol. 1993 May-Jun;38(3):135-7.

PMID:8073753
Abstract

Examinations for the presence of antibody to hepatitis C virus (HCV) were carried out in 144 patients of chronic hemodialysis wards and 83 blood donors. The anti-HCV were found in 26.4% of the patients and only in 1.2% of the blood donors. A definite increase in the incidence of HCV infection in the patients of hemodialysis wards was established in relation to the duration of the treatment, namely from 17.4% in the patients treated for up to 1 year to 37.5% in those treated for 6 years or more. Significant differences were observed in the rate of anti-HCV findings in the patients with kidney transplantation and in those who had not experience this operation. The results obtained by an imitation computer model indicated that the hemotransfusion factor is not the only one determining the high rate of HCV infection in patients of chronic hemodialysis wards, however its influence on the intensity of the epidemic process in hepatitis C in these wards was sufficiently high.

摘要

对144名慢性血液透析病房患者和83名献血者进行了丙型肝炎病毒(HCV)抗体检测。在26.4%的患者中发现了抗HCV,而在献血者中仅为1.2%。与治疗时间相关,血液透析病房患者中HCV感染发生率明显增加,即治疗1年以内的患者中为17.4%,而治疗6年及以上的患者中为37.5%。在肾移植患者和未接受过该手术的患者中,抗HCV检出率存在显著差异。模拟计算机模型得出的结果表明,输血因素并非决定慢性血液透析病房患者HCV高感染率的唯一因素,但其对这些病房丙型肝炎流行过程强度的影响足够大。

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