Schujman L, Lavitula S, Maris Acebal S, Suita G R, Montero A
Hospital de Emergencias Dr. Clemente Alvarez, Rosario, Argentina.
Medicina (B Aires). 1994;54(3):199-202.
Hepatitis C virus (HCV) has been shown to be responsible for a significant proportion of hepatitis cases among patients undergoing frequent blood transfusions. The prevalence in blood serum of anti-HCV antibodies was studied in 48 patients who had undergone dialysis and multiple blood transfusions. In 42 of these patients the average number of transfusions during their treatment was 11.2. The patients were stratified into four groups according to the number of transfusions received (I: < 5, II:6-9, III:10-15 and IV > 15). Odds ratios were used in order to estimate the probability of finding anti-HCV antibodies in groups II, III and IV in relation to the least exposed group I. Anti-HCV antibodies were found in 59% of patients receiving transfusions. As grouped by increasing number of transfusions, each set showed 16, 66, 62.5 and 100% presence of anti-HCV antibodies, respectively. This shows a direct correspondence between the number of transfusions and the serum-born incidence of anti-HCV antibodies. These results closely coincide with those of a similar study, done in the city of Cordoba, Argentina, in 1992. The two studies confirm the necessity to check blood units in order to discard those with anti-HCV antibodies.
丙型肝炎病毒（HCV）已被证明是频繁输血患者中相当一部分肝炎病例的病因。对48例接受透析和多次输血的患者血清中的抗-HCV抗体患病率进行了研究。其中42例患者在治疗期间的平均输血量为11.2次。根据输血量将患者分为四组（I组：<5次，II组：6-9次，III组：10-15次，IV组>15次）。使用比值比来估计II、III和IV组相对于暴露最少的I组中发现抗-HCV抗体的概率。接受输血的患者中有59%检测出抗-HCV抗体。按输血量增加分组，每组抗-HCV抗体的阳性率分别为16%、66%、62.5%和100%。这表明输血量与血清中抗-HCV抗体的发生率之间存在直接对应关系。这些结果与1992年在阿根廷科尔多瓦市进行的一项类似研究的结果非常吻合。两项研究均证实有必要检查血液单位，以丢弃那些含有抗-HCV抗体的血液。
