Gyo K, Kobayashi T, Yanagihara N
Department of Otolaryngology, School of Medicine, Ehime University, Japan.
Acta Otolaryngol Suppl. 1994;514:55-8. doi: 10.3109/00016489409127560.
Hearing impairment caused by sequential rupture of Reissner's membrane and the round window was investigated in guinea pigs to determine if the double-membrane break can cause acute profound sensorineural hearing loss. Reissner's membrane was lacerated through the stria vascularis at one of the turns of the cochlea, followed by rupture of the round window to create leakage of the perilymph. Action potentials (APs) to tone pip stimuli were recorded from the Fallopian canal electrode before and 90 min after these procedures. The results showed that the ears with the double-membrane break at the second turn showed a larger increase in AP threshold than did the control ears with only round window rupture. However, this was not seen when Reissner's membrane had been ruptured at the other turns.
通过在豚鼠身上研究由Reissner膜和圆窗的相继破裂所导致的听力损伤，以确定双膜破裂是否会引起急性重度感音神经性听力损失。在耳蜗的其中一圈处，通过血管纹将Reissner膜划破，随后使圆窗破裂以造成外淋巴渗漏。在这些操作之前和之后90分钟，从面神经管电极记录对短纯音刺激的动作电位（AP）。结果显示，第二圈出现双膜破裂的耳朵，其AP阈值的升高幅度比仅圆窗破裂的对照耳朵更大。然而，当Reissner膜在其他圈破裂时，并未出现这种情况。
