Cassidy A, Bingham S, Setchell K D
Dunn Clinical Nutrition Centre, Cambridge, UK.
Am J Clin Nutr. 1994 Sep;60(3):333-40. doi: 10.1093/ajcn/60.3.333.
The influence of a diet containing soy protein on the hormonal status and regulation of the menstrual cycle was examined in six premenopausal women with regular ovulatory cycles. Soy protein (60 g containing 45 mg isoflavones) given daily for 1 mo significantly (P < 0.01) increased follicular phase length and/or delayed menstruation. Midcycle surges of luteinizing hormone and follicle-stimulating hormone were significantly suppressed during dietary intervention with soy protein. Plasma estradiol concentrations increased in the follicular phase and cholesterol concentrations decreased 9.6%. Similar responses occur with tamoxifen, an antiestrogen undergoing clinical trial as a prophylactic agent in women at high risk for breast cancer. These effects are presumed to be due to nonsteroidal estrogens of the isoflavone class, which behave as partial estrogen agonists/antagonists. The responses to soy protein are potentially beneficial with respect to risk factors for breast cancer and may in part explain the low incidence of breast cancer and its correlation with a high soy intake in Japanese and Chinese women.
在6名有规律排卵周期的绝经前女性中，研究了含大豆蛋白的饮食对激素状态和月经周期调节的影响。每天给予大豆蛋白（60克，含45毫克异黄酮），持续1个月，显著（P<0.01）延长了卵泡期长度和/或推迟了月经。在大豆蛋白饮食干预期间，促黄体生成素和促卵泡激素的中期峰值受到显著抑制。卵泡期血浆雌二醇浓度升高，胆固醇浓度下降9.6%。他莫昔芬（一种正在作为乳腺癌高危女性预防药物进行临床试验的抗雌激素药物）也会出现类似反应。这些作用被认为是由于异黄酮类非甾体雌激素，它们表现为部分雌激素激动剂/拮抗剂。大豆蛋白的这些反应对于乳腺癌的危险因素可能具有潜在益处，并且可能部分解释了日本和中国女性乳腺癌发病率较低及其与大豆高摄入量的相关性。
