Aronson K J, Tomlinson G A, Smith L
Department of Preventive Medicine and Biostatistics, Faculty of Medicine, University of Toronto, Ontario, Canada.
Am J Ind Med. 1994 Jul;26(1):89-101. doi: 10.1002/ajim.4700260108.
Fire fighters are exposed to substances which are recognized or suspected causal agents in cancer or heart disease. The purpose of this study was to determine whether or not fire fighters experience increased risk for any specific cause of death. A retrospective cohort study was conducted, with 5,995 subjects recruited from all six fire departments within Metropolitan Toronto. The mortality experience of the cohort was ascertained through computerized record linkage and compared to that of the male Ontario population specific to cause, age, and calendar period from 1950 through 1989. Average duration of follow-up was 21 years, and there were 777 deaths among the 5,414 males included in the analysis, giving an all-cause standardized mortality ratio of 95 (95% confidence interval: 88-102). Three specific causes of death exhibit statistically significant excesses (brain tumors, "other" malignant neoplasms, and aortic aneurysms). There are also slight increases in risk for some other sites of cancer, and for various diseases of the respiratory, circulatory, and digestive systems. This study is consistent with others in demonstrating that fire fighters experience increased risk of death from cancer of the brain, and in suggesting increased risk for various other causes of death.
消防员会接触到被认为或怀疑是导致癌症或心脏病病因的物质。本研究的目的是确定消防员是否面临因任何特定死因导致的死亡风险增加。开展了一项回顾性队列研究，从大多伦多地区的所有六个消防部门招募了5995名受试者。通过计算机化记录链接确定该队列的死亡情况，并与1950年至1989年按病因、年龄和日历时间段划分的安大略省男性人群的死亡情况进行比较。平均随访时间为21年，纳入分析的5414名男性中有777人死亡，全因标准化死亡比为95（95%置信区间：88-102）。三种特定死因呈现出统计学上的显著超额（脑肿瘤、“其他”恶性肿瘤和主动脉瘤）。其他一些癌症部位以及呼吸、循环和消化系统的各种疾病的风险也略有增加。这项研究与其他研究一致，表明消防员死于脑癌的风险增加，并提示死于其他各种病因的风险增加。
