1988 - 2007年加利福尼亚州消防员患癌风险
Risk of cancer among firefighters in California, 1988-2007.
作者信息
Tsai Rebecca J, Luckhaupt Sara E, Schumacher Pam, Cress Rosemary D, Deapen Dennis M, Calvert Geoffrey M
机构信息
Division of Surveillance, Hazard Evaluations and Field Studies, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, Ohio.
Public Health Institute, Cancer Registry of Greater California, Sacramento, California.
出版信息
Am J Ind Med. 2015 Jul;58(7):715-29. doi: 10.1002/ajim.22466. Epub 2015 May 6.
BACKGROUND
Most studies of firefighter cancer risks were conducted prior to 1990 and do not reflect risk from advances in building materials.
METHODS
A case-control study using California Cancer Registry data (1988-2007) was conducted to evaluate the risk of cancer among firefighters, stratified by race.
RESULTS
This study identified 3,996 male firefighters with cancer. Firefighters were found to have a significantly elevated risk for melanoma (odds ratio [OR] = 1.8; 95% confidence interval [CI] 1.4-2.1), multiple myeloma (OR 1.4; 95%CI 1.0-1.8), acute myeloid leukemia (OR 1.4; 95%CI 1.0-2.0), and cancers of the esophagus (OR 1.6; 95%CI 1.2-2.1), prostate (OR 1.5; 95%CI 1.3-1.7), brain (OR 1.5; 95%CI 1.2-2.0), and kidney (OR 1.3; 95%CI 1.0-1.6).
CONCLUSIONS
In addition to observing cancer findings consistent with previous research, this study generated novel findings for firefighters with race/ethnicity other than white. It provides additional evidence to support the association between firefighting and several specific cancers.
背景
大多数关于消防员癌症风险的研究是在1990年之前进行的，并未反映建筑材料进步带来的风险。
方法
利用加利福尼亚癌症登记处数据（1988 - 2007年）进行了一项病例对照研究，以评估消防员患癌症的风险，并按种族进行分层。
结果
本研究确定了3996名患癌症的男性消防员。发现消防员患黑色素瘤（优势比[OR]=1.8；95%置信区间[CI]1.4 - 2.1）、多发性骨髓瘤（OR 1.4；95%CI 1.0 - 1.8）、急性髓细胞白血病（OR 1.4；95%CI 1.0 - 2.0）以及食管癌（OR 1.6；95%CI 1.2 - 2.1）、前列腺癌（OR 1.5；95%CI 1.3 - 1.7）、脑癌（OR 1.5；95%CI 1.2 - 2.0）和肾癌（OR 1.3；95%CI 1.0 - 1.6）的风险显著升高。
结论
除了观察到与先前研究一致的癌症发现外，本研究还为非白人种族/族裔的消防员得出了新的发现。它提供了更多证据来支持消防员职业与几种特定癌症之间的关联。
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