与DNA结合的小的酸溶性蛋白质可保护枯草芽孢杆菌孢子不被冻干杀死。
Small, acid-soluble proteins bound to DNA protect Bacillus subtilis spores from being killed by freeze-drying.
作者信息
Fairhead H, Setlow B, Waites W M, Setlow P
机构信息
Department of Applied Biochemistry and Food Science, University of Nottingham, Loughborough, Leicestershire, United Kingdom.
出版信息
Appl Environ Microbiol. 1994 Jul;60(7):2647-9. doi: 10.1128/aem.60.7.2647-2649.1994.
Wild-type spores of Bacillus subtilis were resistant to eight cycles of freeze-drying, whereas about 90% of spores lacking the two major DNA-binding proteins (small, acid-soluble proteins alpha and beta) were killed by three to four cycles of freeze-dryings, with significant mutagenesis and DNA damage accompanying the killing. This role for alpha/beta-type small, acid-soluble proteins in spore resistance to freeze-drying may be important in spore survival in the environment.
枯草芽孢杆菌的野生型孢子对八轮冷冻干燥具有抗性，而约90%缺乏两种主要DNA结合蛋白（小的、酸溶性蛋白α和β）的孢子在三到四轮冷冻干燥后死亡，死亡过程伴随着显著的诱变和DNA损伤。α/β型小的、酸溶性蛋白在孢子对冷冻干燥的抗性中的这一作用可能对孢子在环境中的存活很重要。
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