Salo J O, Rannikko S
Urological Department of Helsinki University Central Hospital, Finland.
Ann Med. 1994 Jun;26(3):147-51. doi: 10.3109/07853899409147882.
At present, prostatic cancer is the most common malignancy in men in many Western countries and its incidence is continuously increasing. Radical prostatectomy has been used for over 80 years, but there is still controversy about its role in the treatment of localized prostatic cancer. Because of insufficient knowledge of the natural history of prostatic cancer and a lack of accurate prognostic factors there are possibilities for both over- and undertreatment. Better staging methods are also required to discriminate between intra- and extracapsular tumours, which is essential for curative treatment. On the basis of the facts mentioned above and because of the poor sensitivity and specificity of transrectal palpation, ultrasound examination and prostate-specific antigen, which are used in screening, diagnosing and staging of prostatic cancer, screening is not yet recommended for the detection of early prostatic cancer.
目前,前列腺癌是许多西方国家男性中最常见的恶性肿瘤,其发病率持续上升。根治性前列腺切除术已应用80多年,但对于其在局限性前列腺癌治疗中的作用仍存在争议。由于对前列腺癌自然病史了解不足且缺乏准确的预后因素,存在过度治疗和治疗不足的可能性。还需要更好的分期方法来区分包膜内和包膜外肿瘤,这对于根治性治疗至关重要。基于上述事实,并且由于经直肠触诊、超声检查和前列腺特异性抗原在前列腺癌筛查、诊断和分期中的敏感性和特异性较差,目前不建议进行早期前列腺癌检测的筛查。