与干燥综合征相关的原发性局限性皮肤结节性淀粉样变中淀粉样纤维的特征分析。
Characterization of the amyloid fibril from primary localized cutaneous nodular amyloidosis associated with Sjögren's syndrome.
作者信息
Inazumi T, Hakuno M, Yamada H, Tanaka M, Naka W, Tajima S, Harada T, Nishikawa T
机构信息
Department of Dermatology, Urawa Municipal Hospital, Japan.
出版信息
Dermatology. 1994;189(2):125-8. doi: 10.1159/000246814.
BACKGROUND
Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare disease, and its pathogenesis of amyloid deposition is still unknown.
OBJECTIVE
The purpose of this study was to know the origin of amyloid in PLCNA.
METHODS
Water-soluble amyloid fibrils were isolated from the skin and resolved on SDS-PAGE, then subjected to immunoblot analysis.
RESULTS
The major amyloid fibril protein was a 29-kD peptide which reacted with both anti-lambda- and anti-kappa-light-chain antibodies.
CONCLUSION
Amyloids in this particular case of PLCNA are derived from the polyclonal immunoglobulin light chain and some cases of PLCNA could be reactive diseases rather than neoplastic ones.
背景
原发性局限性皮肤结节性淀粉样变（PLCNA）是一种罕见疾病，其淀粉样沉积的发病机制仍不清楚。
目的
本研究旨在了解PLCNA中淀粉样蛋白的来源。
方法
从皮肤中分离出水溶性淀粉样纤维，并在SDS-PAGE上进行分离，然后进行免疫印迹分析。
结果
主要的淀粉样纤维蛋白是一种29-kD的肽，它与抗λ和抗κ轻链抗体均发生反应。
结论
该特定病例的PLCNA中的淀粉样蛋白来源于多克隆免疫球蛋白轻链，且部分PLCNA病例可能是反应性疾病而非肿瘤性疾病。
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