脂臂霉素，一种来自游动放线菌的新型抗生素。II. 分离、化学、生物学及生物化学特性

Lipiarmycin, a new antibiotic from Actinoplanes. II. Isolation, chemical, biological and biochemical characterization.

作者信息

Coronelli C, White R J, Lancini G C, Parenti F

出版信息

J Antibiot (Tokyo). 1975 Apr;28(4):253-9. doi: 10.7164/antibiotics.28.253.

DOI:10.7164/antibiotics.28.253

Abstract

Lipiarmycin, a metabolite of Actinoplanes deccanensis nov. sp. (PARENTI et al.), has been isolated in pure form. It has a molecular formula C52 CONGRUENT TO 54H74 CONGRUENT TO 76Cl2O19, (M.W. = 1,073 CONGRUENT TO 1,099). From its chemical and physico-chemical characteristics, lipiarmycin can be considered a new antibiotic. Lipiarmycin is highly active against Gram-positive bacteria, including strains resistant to the medically important antibiotics and protects mice experimentally infected with Streptococcus haemolyticus. Liparmycin inhibits growth of susceptible bacteria by interfering with RNA synthesis.

摘要

脂臂霉素是新种德干游动放线菌（PARENTI等人）的一种代谢产物，已被分离出纯品。其分子式为C52近似于54H74近似于76Cl2O19，（分子量 = 1073近似于1099）。从其化学和物理化学特性来看，脂臂霉素可被视为一种新型抗生素。脂臂霉素对革兰氏阳性菌具有高度活性，包括对重要医学抗生素耐药的菌株，并且能保护实验感染溶血性链球菌的小鼠。脂臂霉素通过干扰RNA合成来抑制敏感细菌的生长。