Mellink C, Lahbib-Mansais Y, Yerle M, Gellin J
Laboratoire de Génétique Cellulaire, Centre INRA Toulouse, Castanet-Tolosan, France.
Mamm Genome. 1994 May;5(5):298-302. doi: 10.1007/BF00389544.
The genes coding for the regulatory type I alpha subunit (PRKAR1A) and the catalytic beta subunit (PRKACB) of cAMP-dependent protein kinase and the genes for interleukin 1 alpha (IL1A) and interleukin 1 beta (IL1B) were localized in the pig by means of radioactive in situ hybridization. PRKAR1A was mapped to 12p1.4 and PRKARB to 6q3.1-->q3.3. The genes for IL1A and IL1B were both assigned to Chromosome (Chr) 3, in the region q1.2-->q1.3 and q1.1-->q1.4, respectively. The cDNA nucleotide sequences of these porcine genes were compared with those of human, mouse, and cattle. The location of the genes was discussed in relation to the position of their homologous loci in these mammalian species.
通过放射性原位杂交技术，在猪中定位了编码环磷酸腺苷依赖性蛋白激酶调节性Iα亚基（PRKAR1A）和催化性β亚基（PRKACB）的基因，以及白细胞介素1α（IL1A）和白细胞介素1β（IL1B）的基因。PRKAR1A定位于12p1.4，PRKACB定位于6q3.1→q3.3。IL1A和IL1B的基因均定位于第3号染色体，分别在q1.2→q1.3和q1.1→q1.4区域。将这些猪基因的cDNA核苷酸序列与人类、小鼠和牛的序列进行了比较。讨论了这些基因的定位与这些哺乳动物物种中同源基因座位置的关系。
