Harrison K J, Neumann E, Kalousek D K, Norman M G, Masui S, Harrison K
Cytogenetics/Embryopathology Laboratory, British Columbia Children's Hospital, Vancouver.
Cancer Genet Cytogenet. 1994 Aug;76(1):33-5. doi: 10.1016/0165-4608(94)90066-3.
Many primary pediatric brain tumors are characterized by nonrandom cytogenetic abnormalities involving specific structural rearrangements and loss or gain of specific chromosomes. We describe a low-grade cerebellar astrocytoma with telomeric association of chromosomes 18 and 21 in a 7-year old girl. The nonrandom telomeric association of these chromosomes represents a unique cytogenetic finding in this type of pediatric brain tumor.