质子泵抑制剂奥美拉唑通过一种不依赖尿素酶的机制抑制幽门螺杆菌的酸生存能力。 - Suppr

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超能文献

The proton pump inhibitor omeprazole inhibits acid survival of Helicobacter pylori by a urease-independent mechanism.

作者信息

McGowan C C, Cover T L, Blaser M J

机构信息

Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee.

出版信息

Gastroenterology. 1994 Sep;107(3):738-43. doi: 10.1016/0016-5085(94)90121-x.

DOI:10.1016/0016-5085(94)90121-x

PMID:8076759

Abstract

摘要

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The proton pump inhibitor omeprazole inhibits acid survival of Helicobacter pylori by a urease-independent mechanism.质子泵抑制剂奥美拉唑通过一种不依赖尿素酶的机制抑制幽门螺杆菌的酸生存能力。

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[Antibacterial activity of cefdinir and omeprazole against Helicobacter pylori and their inhibition on H. pylori-producing urease].头孢地尼和奥美拉唑对幽门螺杆菌的抗菌活性及其对幽门螺杆菌产尿素酶的抑制作用

Kansenshogaku Zasshi. 1993 Sep;67(9):808-15. doi: 10.11150/kansenshogakuzasshi1970.67.808.

Omeprazole may exert both a bacteriostatic and a bacteriocidal effect on the growth of Helicobacter pylori (NCTC 11637) in vitro by inhibiting bacterial urease activity.奥美拉唑可通过抑制细菌脲酶活性，在体外对幽门螺杆菌（NCTC 11637）的生长产生抑菌和杀菌作用。

J Clin Pathol. 1998 Mar;51(3):220-4. doi: 10.1136/jcp.51.3.220.

Maastricht II treatment scheme and efficacy of different proton pump inhibitors in eradicating Helicobacter pylori.马斯特里赫特II治疗方案及不同质子泵抑制剂根除幽门螺杆菌的疗效

World J Gastroenterol. 2004 Jun 1;10(11):1656-8. doi: 10.3748/wjg.v10.i11.1656.

The life and death of Helicobacter pylori.幽门螺杆菌的生死

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[A study on acid resistance of Helicobacter pylori].

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Bactericidal activity and synergy studies of proton pump inhibitors and antibiotics against Helicobacter pylori in vitro.质子泵抑制剂与抗生素对幽门螺杆菌的体外杀菌活性及协同作用研究

J Antimicrob Chemother. 1997 Mar;39(3):331-7. doi: 10.1093/jac/39.3.331.

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Effect of gastric acidification on the (14)C-UBT HELIPROBE(®) accuracy during Pantoprazole treatment in Helicobacter pylori positive patients.胃酸化对幽门螺杆菌阳性患者泮托拉唑治疗期间（14）C-尿素呼气试验HELIPROBE（®）准确性的影响。

Int J Clin Exp Med. 2013;6(3):185-91. Epub 2013 Mar 21.

Gastric mucosal inflammatory responses toHelicobacter pylori lipopolysaccharide: suppression of caspase-3 and nitric oxide synthase-2 by omeprazole and sucralfate.幽门螺杆菌脂多糖引起的胃黏膜炎症反应：奥美拉唑和硫糖铝对 caspase-3 和一氧化氮合酶-2 的抑制作用。

Inflammopharmacology. 1999;7(2):163-77. doi: 10.1007/BF02918388.

Helicobacter pylori infection potentiates the inhibition of gastric acid secretion by omeprazole.幽门螺杆菌感染增强了奥美拉唑对胃酸分泌的抑制作用。

Gut. 1999 Apr;44(4):468-75. doi: 10.1136/gut.44.4.468.

Effect of growth phase and acid shock on Helicobacter pylori cagA expression.生长阶段和酸休克对幽门螺杆菌cagA表达的影响。

Infect Immun. 1996 Nov;64(11):4501-7. doi: 10.1128/iai.64.11.4501-4507.1996.

Oxygen concentration influences proton pump inhibitor activity against Helicobacter pylori in vitro.氧浓度在体外影响质子泵抑制剂对幽门螺杆菌的活性。

Antimicrob Agents Chemother. 1996 Jun;40(6):1531-3. doi: 10.1128/AAC.40.6.1531.

Acidic pH changes receptor binding specificity of Helicobacter pylori: a binary adhesion model in which surface heat shock (stress) proteins mediate sulfatide recognition in gastric colonization.酸性pH值改变幽门螺杆菌的受体结合特异性：一种二元黏附模型，其中表面热休克（应激）蛋白在胃部定植过程中介导硫脂识别。

Infect Immun. 1996 Jul;64(7):2643-8. doi: 10.1128/iai.64.7.2643-2648.1996.

A proton pump inhibitor, E3810, has antibacterial activity through binding to Helicobacter pylori.一种质子泵抑制剂E3810通过与幽门螺杆菌结合而具有抗菌活性。

J Gastroenterol. 1995 Aug;30(4):461-4. doi: 10.1007/BF02347561.

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